19 Jan. 2023, our work “Near-infrared phototheranostic iron pyrite nanocrystals simultaneously induce dual cell death pathways via enhanced Fenton reactions in triple-negative breast cancer”has been accepted by ACS Nano
Near-infrared phototheranostic iron pyrite nanocrystals simultaneously induce dual cell death pathways via enhanced Fenton reactions in triplenegative breast cancer
Chunhua Zhao#, Zekun Liu#, Chia-Che Chang, Yi-Chia Chen, Qize Zhang, Xiao-Dong Zhang, Chrysafis Andreou, Jiadong Pang, Ze-Xian Liu *, Di-Yan Wang*, Moritz F.Kircher, Jiang Yang*
Triple-negative breast cancer (TNBC) is considered more aggressive with a poorer prognosis than other breast cancer subtypes. Through systemic bioinformatic analyses, we established the ferroptosis potential index (FPI) based on differentially expressed ferroptosis regulatory genes and found that TNBC has a higher FPI than non-TNBC in human breast cancer cell lines and tumor tissues. To exploit this finding, we developed biologically-amenable phototheranostic iron pyrite (FeS2) nanocrystals (NCs) that efficiently harness near-infrared (NIR) light, as in photovoltaics, for multispectral optoacoustic tomography (MSOT) and photothermal therapy. Upon NIR irradiation that thermodynamically enhances Fenton reactions, dual death pathways of apoptosis and ferroptosis are simultaneously induced in TNBC cells, comprehensively limiting cancer survival by regulating p53, FoxO, and HIF-1 signaling pathways and attenuating a series of metabolisms, including glutathione and amino acids. As a unitary phototheranostic agent with a safe toxicological profile, the nanocrystal represents an effective way to circumvent the lack of therapeutic targets and propensity of metastatic progression in TNBC and simplifies a streamlined workflow of cancer management with an integrated image-guided intervention.
|80||Tsz Chung Yiu , Premkumar Gnanasekaran, Wei-Ling Chen, Wei-Han Lin, Ming-Jun Lin, Di-Yan Wang, Chin-Wei Lu, Chih-Hao Chang*, and Yuan Jay Chang* 2023: Multifaceted Sulfone–Carbazole-Based D–A–D Materials: A Blue Fluorescent Emitter as a Host for Phosphorescent OLEDs and Triplet–Triplet Annihilation Up-Conversion Electroluminescence, ACS Appl. Mater. Interfaces, 2023, 15, 1748–1761.|
28 Sep. 2022, Our work “Fast Charge Transfer between Iodide Ions and Delocalized Electron System on the Graphite Surface for Boosting Hydrogen Production” has been accepted by J. Mater. Chem. A
Fast Charge Transfer between Iodide Ions and Delocalized Electron System on the Graphite Surface for Boosting Hydrogen Production. just accepted by J. Mater. Chem. A
Shih-Mao Peng,1 Shivaraj B. Patil,1 Chun-Chih Chang,2 Shu-Ting Chang,1 Yi-Chia Chen,1 Kuan-Chang Wu,1 Wei-Nien Su,3,4* Bing Joe Hwang,4,5,6* Di-Yan Wang1*
Developing new catalysts to reduce the energy barrier for hydrogen production from water splitting has been an important research topic. It is well-known that the water-splitting voltage is limited by a theoretical potential of 1.23 V of oxygen evolution reaction (OER). Recently, a new electrolytic method using iodide oxidation reaction (IOR) instead of OER has been proposed to produce valuable chemical iodine and hydrogen efficiently by a reduced operating voltage. In this work, we found that the graphite-based materials with a delocalized p electron system exhibited fast charge transfer with physically adsorbed iodide ions, thus revealing desirable IOR catalytic activity. The carbon fiber paper with a graphite structure was chosen as the catalyst and exhibited the onset potential of 0.54V (vs. RHE) for IOR, which is close to the standard potential of iodide oxidation. Also, the CFP demonstrated a minimum Tafel slope of 47.78 mV/dec in the electrochemical reaction with significant stability at the current density of 10 mA/cm2 for over 18 hours. Moreover, in a two-electrode system, a cell voltage of only 0.59 V was required to provide a current density of 10 mA/cm−2 for the IOR and hydrogen evolution reaction (HER). Based on energy costs, our HER and IOR system can reduce energy consumption by 65% compared to conventional OER-based water electrolysis. The overall results indicate that our findings pave a new route to facilitate the industrial application of hydrogen production via electrochemical reactions.